Nora Bengoa-Vergniory has shown that compounds known as molecular tweezers could become a promising disease modifying therapy for Parkinson's.
Key Fob Brain
A team of researchers has shown that tiny compounds known as molecular "tweezers" could become a promising therapy to slow Parkinson's. This new kind of drug works by pulling apart toxic clumps of protein that form in the brain during Parkinson's.
The therapy has previously shown high potential for targeting toxic protein clumps that form in neurodegenerative conditions such as Alzheimer's.
The research teams therefore investigated whether a particular molecular tweezer, CLR01, was able to reduce formation of protein clumps in cell and mouse models of Parkinson's. The study showed that CLR01 is able to decrease clusters of the Parkinson's protein alpha-synuclein forming and prevent the death of human neurons that were made from stem cells. Researchers tested CLR01 in a mouse model of Parkinson's that stimulates the formation of protein clusters and mimics the motor symptoms experienced by people with the condition, which can include tremor and slowness of movement.
As the mice aged, CLR01 treatment reduced the appearance of motor problems and the formation of toxic protein clusters in the brain. Importantly, the team showed that in much older animals with more progressed Parkinson's, CLR01 treatment was less effective.
This work shows that using protective therapies early on in Parkinson's is essential for an effective treatment.How to extend the range of a key fob - HINT: Your Head
These combined results highlight that CLR01 represents a candidate to treat Parkinson's, and highlights the need for further research in this area.
Lead Researcher Dr. Nora Bengoa-Vergniory said, "Future investment to determine the appropriate therapeutic window for these kinds of therapeutic agents is crucial for the success of these and other therapeutic strategies. Head of the Oxford Parkinson's Disease Center and senior author on the study Professor Richard Wade-Martins said, "This is a very exciting piece of work showing that drug treatments can be developed to unpick toxic protein clusters to save neurons in models of Parkinson's.
Our work is focused on developing new approaches to saving neurons when they start to lose function early on, but before they die later on in the condition. This is a very exciting piece of work showing that drug treatments can be developed to unpick toxic protein clusters to save neurons in models of Parkinson's.
This work should give encouragement to those ultimately hoping for protective therapies. Beckie Port, research manager at Parkinson's UK, said, "We desperately need treatments that protect brain cells in Parkinson's. These findings show that this innovative 'molecular tweezer' approach has exciting potential in the lab. We now need to take this therapy forward to test in clinical trials—only then will we know whether it can do the same in people with Parkinson's.Watch closely as Canadian Ricky Tang walks away from his car, attempts to lock it from a distance, fails, and then uses his own head as a transmitter to lock the car with his remote.
Notice how far Tang is from the black car at the end of the lot. Pointing his key fob at the car from this distance fails, but pointing it at his head doubles the distance that it can work.
For real. Credit: Science Channel. The key pun intended is water. Not a great one, but it works. Even though this trick has been well known for years, few people seem to be aware of it. The popular U. Scientists say yes. A car remote only produces a small amount of electrical power for a small amount of time.
Your brain, they claim, can handle it. We immediately tried this one ourselves. And though you might feel like a fool pointing your key fob at your chin, this trick works. We tried it from roughly feet away, and still saw our lights flash. Not Just For Cooking! Let Yahoo Makers inspire you every day! Search News Search web. Kelly Phillips Badal Editor. Story continues. Our goal is to create a safe and engaging place for users to connect over interests and passions.
In order to improve our community experience, we are temporarily suspending article commenting. What to Read Next. Associated Press.
Yahoo Celebrity. Yahoo News. Yahoo News Video. Yahoo News Photo Staff. Yahoo Life. NBC News. Who What Wear. Yahoo Sports. Yahoo Finance. Yahoo TV.My pocket was always mysteriously opening my trunk. After a bit of thought, I realized this was because my keys were in there and hitting the trunk open button on my key fob. I tend not to use my key fob to open my trunk that much.
After looking through my manual I couldn't find a way to disable the key fob button to open the trunk and keep the button in the cabin working.
I suppose going into the car's computer could do it, but I'm not the computer hacking type. What I have here is a simple, fast and easy, fully reversible way to disable any button on a key fob. My car is a GM, I know other brands use a similar system, but your car may vary. Materials: Little bit of plastic bagging Tools: Scissors, coin, brain, hands. I don't like magic. If you know electric theory at all, you probably won't need to know this.
But if you don't, this will demystify it. The buttons on a key fob work by having a conductive pad touch an open circuit on the Printed Circuit Board PCB and therefore close it. All that has to be done is stop the circuit from completing. We need an insulator between them to disable the button. These things are made to be dissembled to get to the battery.
Twinkling, star-shaped brain cells may hold the key to why, how we sleep
All you have to do is crack it open with a coin, I used my house key, at the wide spot. Pull out the rubber buttons and circuit board, the pull the PCB out of the buttons. Takes about thirty seconds. Use a small bit of plastic sheet, like from a bag, and cut it to be big enough to cover the pad and stay in place, but small enough to fit in the button.
Then simply place it on the conductive pad of the button you wish to put to sleep. Undoing the whole project just involves the reverse of this step, take the plastic out and make it part of the bag it came from. Or just the first part of that sentence. Just orient the board and the buttons, seat the board, seat the buttons, then snap the back on and you're done.
Took me about 3 minutes to do as a whole. Question 3 months ago. Stopped at a rest area on way home. While taking a nap in my front seat someone opened up my back door. The doors were locked but because I had the key on me this person just pulled on the handle and opened the door. I have asked the dealer and several individuals that also have a FOB. Dealer had no idea and the people I asked were shocked because they hadn't thought about that and had no idea how to correct it.
It must be a simple fix. I'm not going to dismantle my FOB to get around it. Please help, I travel quite a bit Good idea. I did this with my alarm button, but I just cut the button out, your way is less destructive.
Reply 6 years ago on Introduction. I just used masking tape under my panic button, concept is the same though. Seemed I kept bumping it when I bought a new fob.
Problem solved. Introduction: Disabling a Key Fob Button.Beach Automotive Group has you covered! Many new Ford vehicles come with a remote key fob for easier vehicle access. Programming a new key fobis is simple if your car is equipped with keyless entry and you know the steps.
Conway and Murrells Inlet Ford owners can follow our quick guide below! Do you have questions about Ford key fob programming, or are you having difficulties with set-up? Schedule a service appointment near Florence and Wilmington. Our certified technicians can answer your questions about Ford accessories and walk you through the key fob programming steps and teach you how to use Ford remote start. Check out Ford F lift kits to make the most of your Wilmington drive! Awesome Tire Information!
Your tire treads have extremely important jobs to do, including maintaining traction and evacuating water and other liquids out from under the tires during operation. Read More. Ford pickups have long set the standard for power, performance, and style. While choosing the right pickup for your needs might seem challenging, it does not have to be. You can trust Ford to offer new vehicles and vehicular updates every year, which stands as a testament to their dedication to always evolve their products and services with time.
The Ford brand is synonymous with reliable and high-quality vehicles at affordable prices. The automobile manufacturing brand is always trying to provide its customers with…. Your email address will not be published. Now, my main question is, do you have a guide to reprogramming the key itself? Any help will be appreciated. Thanks for the information. Can you clarify whether the procedure will work for one of the two original key fobs that no longer works?
In short, I have one that works and one that no longer works. My original Ford keys were really worn out. I found all of the procedures to program the key but nobody else mentioned that the buttons are programmed using a different mode. With elevated frustration, I finally stumbled across your site.
Tiny brain 'tweezers' could hold the key to treating Parkinson's Disease
Your guide saved the day! All 4 keys now function exactly as their Ford factory counterparts. Thank you!!! I have a Ford vehicle which uses a 3 button remote, and the car has push button start. Do you have instructions for vehicles with push button start?
My Ford car does not a have an ignition that uses a key. It uses push button start. Do have instructions on how to program the keyfob for a push button start vehicle? At the local airport pdx my keyless system goes dead. Ford Explorer Key Fob Brain. Alpha should correct the problem and issue a Key recall. That signal is amplified with a battery in the key fob, which helps explain why the range of the fob decreases as its battery wears out. See full list on corvettesalvage. Also, if a custom alarm setting is used, it would be nice if the fob matched the app.
They are vital in an emergency to Start the bikes electrical system. Open the drivers door and sit in the drivers seat. What does key fob actually mean? Find out inside PCMag's comprehensive tech and computer-related encyclopedia. This key fob has two buttons; one shines an LED like a flashlight and the other turns off televisions.
None on the steering column, glove box or rear hatch door. I don't think it was pre-tested much before being produced but they do indeed need to be fixed. I was sitting around the other day playing with my son and his hot wheels when I got another random idea what about putting my key fob into a hot wheel better yet an xb hot wheel well after a few days of brain storming I went to work and ended up wi th one of the coolest things I have done.
The handbook specifies 2 x for each. Fortunately, they are easy to repair. I have to press the open button say, 5 times before it actually opens, same with the lock and boot!? Do you have to change the battery or something, or do i have to get a completly new one? Also, to open the boot, is there any way of opening it inside rather that just on the key fob?. The fob brain off of my broken one fit exactly like the factory one.
Open brain box cover b. Send us your enquiry today. Battery Brain.September 24, A new study published today in the journal Current Biology suggests that star-shaped brain cells known as astrocytes could be as important to the regulation of sleep as neurons, the brain's nerve cells. Floyd College of Medicine, the study builds new momentum toward ultimately solving the mystery of why we sleep and how sleep works in the brain.
The discovery may also set the stage for potential future treatment strategies for sleep disorders and neurological diseases and other conditions associated with troubled sleep, such as PTSD, depression, Alzheimer's disease, and autism spectrum disorder. Neurons, she explained, communicate through electrical signals that can be readily captured through electroencephalography EEG.
Astrocytes—a type of glial or "glue" cell that interacts with neurons—do not use electrical signals and instead use a process known as calcium signaling to control their activity. It was long thought that astrocytes—which can outnumber neurons by five to one—merely served a supportive role, without any direct involvement in behaviors and processes. Neuroscientists have only recently started to take a closer look at their potential role in various processes.
And while a few studies have hinted that astrocytes may play a role in sleep, solid scientific tools to study their calcium activity have not been available until recently, Ingiosi said. To delve deeper into astrocytes' role in sleep, she and her coauthors used a rodent model to record astrocytes' calcium activity throughout sleep and wake, as well as after sleep deprivation. They used a fluorescent calcium indicator that was imaged via tiny head-mounted microscopes that looked directly into the brains of mice as they moved around and behaved as they normally would.
This indicator allowed the team to see calcium-driven fluorescent activity twinkling on and off in astrocytes during sleep and waking behaviors. Their one-of-a-kind methodology using these miniature microscopes allowed the team to conduct the first-ever study of astrocytes' calcium activity in sleep in freely behaving animals.
The research team set out to answer two main questions: do astrocytes change dynamically across sleep and wake states like neurons do? And do astrocytes play a role in regulating sleep need, our natural drive to sleep?
Looking at astrocytes in the frontal cortex, an area of the brain associated with measurable EEG changes in sleep need, they found that astrocytes' activity changes dynamically across the sleep-wake cycle, as is true for neurons. They also observed the most calcium activity at the beginning of the rest phase—when sleep need is greatest—and the least calcium activity at the end of the test phase, when the need for sleep has dissipated.
Next, they kept mice awake for the first 6 hours of their normal rest phase and watched calcium activity change in parallel with EEG slow wave activity in sleep, a key indicator of sleep need. That is, they found that sleep deprivation caused an increase in astrocyte calcium activity that decreased after mice were allowed to sleep.
Their next question was whether genetically manipulating astrocyte calcium activity would impact sleep regulation. To find out, they studied mice that lacked a protein known as STIM1 selectively in astrocytes, which reduced the amount of available calcium. After being sleep deprived, these mice did not sleep as long or get as sleepy as normal mice once allowed to sleep, which further confirmed earlier findings that suggest that astrocytes play an essential role in regulating the need for sleep.
Finally, they tested the hypothesis that perhaps astrocyte calcium activity merely mirrors the electrical activity of neurons. Studies have shown that the electrical activity of neurons becomes more synchronized during non-REM sleep and after sleep deprivation, but the researchers found the opposite to be true for astrocytes, with calcium activity becoming less synchronized in non-REM sleep and after sleep deprivation.
More research is needed to further unravel the role of astrocytes in sleep and sleep regulation, Ingiosi said.
She plans to study astrocytes' calcium activity in other parts of the brain that have been shown to be important for sleep and wake. In addition, she would like to look at astrocytes' interactions with different neurotransmitters in the brain to start to tease out the mechanism by which astrocytes might drive sleep and sleep need. Your feedback will go directly to Science X editors. Thank you for taking your time to send in your valued opinion to Science X editors. You can be assured our editors closely monitor every feedback sent and will take appropriate actions.
Your opinions are important to us. We do not guarantee individual replies due to extremely high volume of correspondence. E-mail the story Twinkling, star-shaped brain cells may hold the key to why, how we sleep Your friend's email Your email I would like to subscribe to Science X Newsletter. Learn more Your name Note Your email address is used only to let the recipient know who sent the email. Neither your address nor the recipient's address will be used for any other purpose.
The information you enter will appear in your e-mail message and is not retained by Medical Xpress in any form. You can unsubscribe at any time and we'll never share your details to third parties.Ultimately, we see Microsoft Whiteboard Preview as enhancing how people go from personal ideation, team brainstorms, and group discussions to their finished products. Now even remote workers can easily join in and contribute to the discussion.
Microsoft Whiteboard Preview lets you create in whatever way feels most natural to you. The pen-first, touch-first technology lets you make fluid gestures with your fingers or draw out finer details with your pen. Using your pen, you can jot down notes, draw precise illustrations, or search for images on the web. Using your fingers, you can swipe to different sections of your board, turn the virtual ruler to the angle you want, and drag and drop images to create a photo stack.
Whether you use pen or touch, Microsoft Whiteboard Preview recognizes your intent and delivers your desired outcomes in an instant. And unlike traditional whiteboards, the app automatically saves your boards, so you can pick up where you left off or share links to your boards, so others can build on top of your work. We look forward to receiving your comments, suggestions, and feature requests via the Windows Feedback Hub, which you can access from within the app. The app is free to use for anyone with a Windows 10 device, but one participant with an Office 365 personal, work, or school account is needed for multi-party collaboration.
For SurfaceHub customers, the Microsoft Whiteboard Preview will eventually replace the native whiteboard app currently running on your SurfaceHub. In the meantime, you can install the preview of the Microsoft Whiteboard alongside your existing app.
Tell us what you love, what you could do without, and what you want more of by completing quests, surveys, quick polls, and reporting problems directly to developers. Getting started as an Xbox Insider is as easy as downloading the Xbox Insider Hub app on your Xbox One or PC. Each Insider content preview has different requirements to participate.
To view the requirements for each preview:Note Only previews you're eligible to participate in will appear in Insider content.
Additionally, there are often different Insider content previews available on Xbox One and Windows 10, as some programs are specific to a given platform. See the Xbox Insider Program agreement. Note that the available Update Preview ring(s) you can register with will be based on your Xbox Insider XP score and tenure in the program. There are four Xbox One Update Preview rings, which allow you control when and how often you will get early access to console updates.
Do I need to join Xbox One Update Preview to participate in game or app previews available through the Xbox Insider Program. Not all previews will be available to all Xbox Insiders.
Participants can be eligible for previews based on a variety of factors, which may be different for each Xbox Insider preview. In some cases, the game or app developer may decide on eligibility themselves.
Eligibility can also be determined based on your interests, previous activities in the Xbox Insider Program, tenure as an Xbox Insider, Xbox Insider XP score, games you own, and more.
Occasionally we will automatically enroll users who meet certain simple criteria in an Insider program. For example, all Insiders who launch the Xbox Insider Hub and agree to the Terms and Conditions are automatically enrolled in the Xbox Insider Program. Generally this is done to expose qualified users to certain announcements, quests, and so we can learn about your interests and notify you of new opportunities.
You may gain access to new Insider content through these programs. I sold my console or no longer wish to participate as an Xbox Insider. How can I stop participating in the Xbox Insider Program. The same steps apply if you intend to keep your console but no longer wish to participate as an Xbox Insider and would like to unenroll your console from the program.